MACE-plus endpoints
Expanded composite cardiovascular outcomes including traditional MACE plus additional clinically relevant events. Used to capture broader treatment benefits in prevention trials.
Full Definition
MACE-plus endpoints represent expanded composite cardiovascular outcomes that include traditional major adverse cardiovascular events (cardiovascular death, myocardial infarction, stroke) plus additional clinically relevant endpoints such as coronary revascularization, hospitalization for unstable angina, or heart failure. These broader composite endpoints are increasingly used in cardiovascular prevention trials to capture the full spectrum of treatment benefits, particularly for interventions that may reduce less severe but clinically meaningful events. While providing greater statistical power, MACE-plus endpoints require careful interpretation regarding clinical significance of individual components.
Usage
Usage note: Distinguish from traditional three-point MACE; specify included components when reporting results.
In Context
- "The trial used MACE-plus endpoints including revascularization to demonstrate the full clinical benefit of intensive lipid lowering." — Clinical trial methodology
- "MACE-plus endpoints captured a 25% relative risk reduction compared to 15% for traditional three-point MACE." — Cardiovascular outcomes research