MACE
Pronunciation: mace (like the spice)
Also written as: MACE — Major Adverse Cardiovascular Events
Major adverse cardiovascular events, a composite endpoint used in clinical trials and outcomes research.
Full Definition
Major adverse cardiovascular events (MACE) represents a standardized composite endpoint commonly used in cardiovascular clinical trials and epidemiological studies. The traditional MACE definition includes cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke, though some studies expand this to include urgent revascularization procedures. MACE serves as the primary endpoint for evaluating the efficacy of preventive interventions and represents clinically meaningful outcomes that matter to patients and healthcare systems. The time to first MACE event is typically analyzed using survival analysis methods. Different studies may use slight variations in MACE definitions, so careful attention to the specific components is essential when interpreting research findings.
Usage
Usage note: Always specify the exact MACE definition used in the study being discussed, as components may vary.
In Context
- "The study demonstrated a 25% reduction in MACE with intensive lipid-lowering therapy over five years." — Clinical trial results
- "MACE occurred in 8.2% of the treatment group compared to 11.7% of controls during the follow-up period." — Outcomes research publication