drug-eluting stent
Coronary stent coated with antiproliferative medication to reduce restenosis rates.
Full Definition
A drug-eluting stent (DES) is an expandable metallic scaffold coated with a polymer that slowly releases antiproliferative or immunosuppressive drugs to prevent smooth muscle cell proliferation and reduce in-stent restenosis. Common drug coatings include sirolimus, paclitaxel, everolimus, and zotarolimus, each with specific release kinetics and biological effects. DES technology has evolved through multiple generations, with newer-generation stents featuring biocompatible or biodegradable polymers and improved drug formulations. DES significantly reduces restenosis rates compared to bare metal stents but requires prolonged dual antiplatelet therapy to prevent stent thrombosis.
Usage
Usage note: Distinguish from drug-coated balloons which don't leave permanent implant
In Context
- "A second-generation drug-eluting stent was deployed in the mid-LAD stenosis." — Procedure report
- "Drug-eluting stent thrombosis remains a rare but serious late complication." — Complication review