TCFA
Also written as: TCFA — Thin-Cap Fibroatheroma
High-risk coronary plaque characterized by a large lipid core covered by a thin fibrous cap prone to rupture.
Full Definition
Thin-Cap Fibroatheroma (TCFA) represents the most dangerous type of coronary atherosclerotic plaque, characterized by a large necrotic lipid core covered by a thin fibrous cap typically less than 65 micrometers thick. These plaques are highly vulnerable to rupture due to inflammatory cell infiltration and proteolytic enzyme activity that weakens the fibrous cap. TCFA identification through advanced imaging modalities like OCT or NIRS is crucial for risk stratification, as these lesions are responsible for the majority of acute coronary syndromes even when not causing significant luminal stenosis.
Usage
Usage note: Plural form is 'TCFAs' or 'thin-cap fibroatheromas'.
In Context
- "OCT identified multiple TCFAs in the proximal LAD despite minimal angiographic stenosis." — Imaging study report
- "The presence of TCFA was associated with increased risk of future cardiovascular events." — Prognostic study