thrombolytic therapy
Medical treatment using clot-dissolving medications to restore blood flow in occluded coronary arteries during acute MI.
Full Definition
Thrombolytic therapy involves the administration of fibrinolytic agents that activate the body's natural clot-dissolution mechanism to recanalize thrombotically occluded coronary arteries. Common thrombolytic agents include tissue plasminogen activator (tPA), streptokinase, and reteplase. This treatment is primarily used in ST-elevation myocardial infarction (STEMI) when primary percutaneous coronary intervention is not immediately available. Successful thrombolysis can restore TIMI 2 or 3 flow and salvage myocardium, but carries risks of bleeding complications including intracranial hemorrhage. The effectiveness diminishes with time, making prompt administration within the first few hours of symptom onset crucial for optimal outcomes.
Usage
Usage note: Use 'thrombolytic' as the adjective form; 'thrombolysis' refers to the process itself.
In Context
- "Thrombolytic therapy was initiated with tenecteplase for the patient presenting with acute anterior STEMI." — Emergency department note
- "Successful thrombolysis was evidenced by resolution of ST-elevation and improved chest pain." — Cardiology progress note