DAPT
Also written as: DAPT — Dual Antiplatelet Therapy
Dual antiplatelet therapy combining aspirin with a P2Y12 inhibitor to prevent thrombotic events after percutaneous coronary intervention.
Full Definition
Dual antiplatelet therapy (DAPT) is the cornerstone of antithrombotic treatment following percutaneous coronary intervention, typically combining aspirin with a P2Y12 receptor inhibitor such as clopidogrel, prasugrel, or ticagrelor. The optimal duration of DAPT balances ischemic protection against bleeding risk, with contemporary research focusing on personalized duration strategies based on patient and procedural characteristics. DAPT duration recommendations vary from 1-12 months depending on stent type, bleeding risk, and clinical presentation. Recent trials have evaluated abbreviated DAPT regimens and novel dual pathway inhibition strategies.
Usage
Usage note: Always capitalize when referring to the scoring system (DAPT Score) but can be lowercase when used generically.
In Context
- "The trial protocol specified DAPT duration of 12 months for all patients receiving drug-eluting stents." — Clinical trial protocol
- "DAPT Score assessment guided personalized antiplatelet therapy duration in the study cohort." — Research methodology