Cardiovascular Research Glossary

Standardized clinical endpoint definitions developed to ensure consistency across cardiovascular device trials.

Complete occlusion of a coronary artery during or immediately after percutaneous coronary intervention.

Independent expert panel that reviews and classifies clinical events in cardiovascular trials to ensure consistent endpo...

Death from any cause, used as a hard clinical endpoint in cardiovascular trials to avoid adjudication bias.

Narrowing of a previously treated coronary artery segment as visualized on coronary angiography, typically defined as ≥5...

Medication regimen using drugs that inhibit platelet aggregation to prevent thrombotic cardiovascular events.

Diameter stenosis of 50% or greater at follow-up angiography in a previously treated vessel segment.

A measurable biological indicator of normal biological processes, pathogenic processes, or pharmacologic responses to th...

Standardized bleeding classification system specifically developed for cardiovascular research studies.

Surgical procedure creating alternate pathways around blocked coronary arteries using vessel grafts.

Specialized facility where invasive cardiac procedures are performed using fluoroscopic guidance.

Subspecialty field addressing cardiovascular complications of cancer and cancer therapies, including prevention, monitor...

Death resulting from cardiovascular causes, including coronary heart disease, heart failure, stroke, or sudden cardiac d...

Advanced cardiac imaging technique using magnetic resonance technology to assess cardiac structure and function.

An independent committee of clinical experts who review and classify clinical events in a standardized manner to ensure...

Independent group of medical experts who adjudicate and classify cardiovascular events in clinical trials.

Standardized definitions and categorization system for adverse events in cardiovascular research studies.

A primary outcome measure that combines multiple related clinical events into a single endpoint to increase statistical...

The ratio of maximum coronary blood flow to resting coronary blood flow, used to assess coronary microvascular function.

The ratio of peak coronary flow velocity during maximal hyperemia to baseline flow velocity.

Impaired function of small coronary vessels (<500 μm) that cannot be visualized on conventional angiography, causing isc...

A standardized document used to collect clinical trial data for each study participant in a systematic and organized man...

Complete coronary artery blockage present for at least 3 months, representing complex lesions requiring specialized inte...

The coronary artery determined to be responsible for an acute coronary syndrome or myocardial infarction.