late lumen loss
The difference between immediate post-procedural minimal lumen diameter and minimal lumen diameter at follow-up angiography, indicating restenosis progression.
Full Definition
Late lumen loss (LLL) is a quantitative angiographic measure used to assess restenosis after percutaneous coronary interventions, particularly important in drug-eluting stent research. LLL is calculated as the minimal lumen diameter immediately after stent implantation minus the minimal lumen diameter at follow-up angiography (typically 6-9 months). This measurement provides a continuous variable for assessing the degree of neointimal hyperplasia and vessel renarrowing over time. LLL values are typically reported in millimeters and serve as a surrogate endpoint for clinical restenosis, with lower values indicating better long-term vessel patency and reduced need for repeat revascularization.
Usage
Usage note: Express in millimeters with appropriate precision (typically to 0.01mm); avoid confusion with percentage measures.
In Context
- "Late lumen loss was significantly reduced in the drug-eluting stent group compared to bare metal stents (0.23mm vs 0.85mm)." — Angiographic results
- "Quantitative coronary angiography was performed to measure late lumen loss at 9-month follow-up." — Methods section