MACE
Pronunciation: MAYSS
Also written as: MACE — Major Adverse Cardiovascular Events
A composite endpoint commonly used in cardiovascular trials, typically including cardiovascular death, myocardial infarction, and stroke.
Full Definition
Major Adverse Cardiovascular Events represents a standardized composite endpoint widely adopted in cardiovascular clinical trials to capture the most clinically relevant outcomes. The traditional three-point MACE includes cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke. Extended definitions may include urgent revascularization, hospitalization for heart failure, or all-cause mortality depending on study objectives. MACE provides statistical efficiency by increasing event rates while maintaining clinical relevance. Regulatory agencies typically require pre-specified hierarchical testing procedures for MACE components to control Type I error.
Usage
Usage note: Always specify the components of MACE used in each study; distinguish from MACCE (Major Adverse Cardiovascular and Cerebrovascular Events).
In Context
- "The study was powered to detect a 20% reduction in three-point MACE over two years." — Study design manuscript
- "Four-point MACE occurred in 12.3% of patients in the treatment arm versus 15.1% in placebo." — Primary results publication