no-reflow phenomenon
Impaired myocardial perfusion despite successful epicardial coronary artery recanalization following PCI.
Full Definition
No-reflow phenomenon describes the clinical situation where adequate epicardial coronary flow is restored but myocardial tissue perfusion remains impaired, typically due to microvascular dysfunction or obstruction. This complication occurs in 5-15% of primary PCI cases and is associated with larger infarct size, reduced left ventricular function, and worse clinical outcomes. In cardiovascular research, no-reflow is assessed using angiographic criteria (TIMI flow grade <3), electrocardiographic criteria (ST-segment resolution <70%), or imaging modalities. Editors should ensure consistent definition criteria are applied throughout studies examining this phenomenon.
Usage
Usage note: Hyphenate when used as an adjective. Specify assessment criteria (angiographic, ECG, or imaging-based).
In Context
- "No-reflow phenomenon occurred in 12% of patients despite successful stent deployment." — Primary PCI outcomes study
- "Pretreatment with glycoprotein IIb/IIIa inhibitors reduced the incidence of no-reflow." — Interventional pharmacology trial