patient-oriented composite endpoint
Also written as: POCE — Patient-Oriented Composite Endpoint
A composite outcome measure that includes all-cause death, any myocardial infarction, and any revascularization.
Full Definition
Patient-oriented composite endpoint (POCE) is a broad composite outcome measure designed to capture all clinically relevant adverse events from a patient's perspective, regardless of their relationship to the study device or procedure. POCE typically includes all-cause death, any myocardial infarction (not just target vessel-related), and any revascularization (including both target and non-target vessel procedures). This endpoint provides a comprehensive assessment of overall patient outcomes and is less subject to adjudication bias compared to device-oriented endpoints. POCE is particularly valuable in cardiovascular research for evaluating the overall safety and effectiveness of interventions from a real-world clinical perspective. The endpoint acknowledges that patients experience all adverse events equally, regardless of their mechanistic relationship to the study intervention.
Usage
Usage note: Clearly distinguish from device-oriented endpoints in study protocols.
In Context
- "The patient-oriented composite endpoint occurred in 12.4% of patients at one year." — Clinical trial results
- "Secondary analysis focused on the patient-oriented composite endpoint to assess overall clinical impact." — Study methodology