glioblastoma multiforme
Pronunciation: glee-oh-blas-TOH-mah mul-tih-FOR-mee
A highly malignant primary brain tumor, the most aggressive form of glioma, commonly abbreviated as GBM.
Full Definition
Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor in adults, arising from astrocytes and characterized by rapid growth, invasive behavior, and poor prognosis. The tumor exhibits heterogeneous cellular morphology with areas of necrosis and vascular proliferation, giving rise to the 'multiforme' designation. GBM is classified as a Grade IV astrocytoma according to the World Health Organization classification and typically presents with progressive neurological deficits, seizures, or increased intracranial pressure. Standard treatment involves maximal safe surgical resection followed by concurrent radiation therapy and temozolomide chemotherapy, though median survival remains approximately 15 months.
Usage
Usage note: May be abbreviated as GBM after first use; ensure proper capitalization of 'multiforme' as part of formal name.
In Context
- "The pathology report confirmed glioblastoma multiforme with IDH-wildtype status and MGMT promoter methylation." — Oncology consultation note
- "Imaging characteristics of this enhancing lesion with central necrosis are consistent with glioblastoma multiforme." — Radiology report