Intermediate
Technical
IVT
Cutaneous Squamous Cell Carcinoma
A malignant tumor arising from keratinocytes in the epidermis, representing the second most common form of skin cancer.
Full Definition
Cutaneous squamous cell carcinoma (cSCC) is a malignant neoplasm originating from keratinocytes in the epidermis or its appendages. Unlike basal cell carcinoma, cSCC has metastatic potential, particularly in high-risk locations such as the ears, lips, and genitalia. Risk factors include chronic sun exposure, immunosuppression, and human papillomavirus infection. Treatment typically involves surgical excision with histopathologic margin assessment.
Usage
Usage note: Always specify 'cutaneous' to distinguish from squamous cell carcinomas of other organs.
In Context
- "The pathology report confirmed invasive cutaneous squamous cell carcinoma with clear margins." — Surgical pathology report
- "Given the patient's history of organ transplantation, surveillance for cutaneous squamous cell carcinoma was increased." — Clinical consultation note
Also known as
cSCC
cutaneous SCC
squamous cell carcinoma of skin
Don't confuse with
keratoacanthoma
seborrheic keratosis
actinic keratosis