Keratoacanthoma
Pronunciation: ker-ah-toe-ah-can-THO-mah
A rapidly growing, dome-shaped lesion with a central keratotic plug that may spontaneously resolve but requires differentiation from squamous cell carcinoma.
Full Definition
A keratoacanthoma (KA) is a distinctive skin lesion that presents as a rapidly growing, dome-shaped nodule with a central crater filled with keratin. These lesions typically develop over weeks to months and may spontaneously involute, but they are clinically and histologically difficult to distinguish from squamous cell carcinoma. The lesion is thought to arise from hair follicles and is associated with sun exposure, trauma, or viral infections. Due to the diagnostic uncertainty and potential for aggressive behavior, most dermatologists recommend complete excision rather than observation.
Usage
Usage note: Always consider in differential diagnosis of rapidly growing lesions; abbreviate as KA after first use.
In Context
- "The rapid growth pattern suggested keratoacanthoma, but excision was recommended to rule out squamous cell carcinoma." — Clinical note
- "Histopathology showed features consistent with keratoacanthoma rather than invasive carcinoma." — Pathology report