peak and trough levels
Blood tests measuring highest and lowest concentrations of psychiatric medications to ensure therapeutic dosing and prevent toxicity.
Full Definition
Peak and trough levels are laboratory measurements used to monitor psychiatric medications with narrow therapeutic windows, such as lithium and certain anticonvulsants. Peak levels measure the highest blood concentration (typically drawn 1-2 hours after dosing), while trough levels measure the lowest concentration (drawn just before the next dose). In emergency psychiatry, these levels help clinicians assess medication compliance, adjust dosing, and identify potential toxicity in patients presenting with altered mental status or medication-related side effects.
Usage
Usage note: Always use 'and' rather than ampersand when writing out the full term.
In Context
- "Peak and trough levels were ordered to evaluate the patient's lithium toxicity." — Laboratory order documentation