everolimus

Full Definition

Everolimus is an oral inhibitor of the mammalian target of rapamycin (mTOR) pathway that demonstrates antiproliferative effects in neuroendocrine tumors. It is approved for treatment of advanced pancreatic, lung, and gastrointestinal neuroendocrine tumors that are locally advanced, metastatic, or unresectable. The drug works by blocking cellular signaling pathways involved in tumor growth, angiogenesis, and glucose metabolism. Common side effects include stomatitis, rash, fatigue, and metabolic abnormalities requiring monitoring.

Usage

Usage note: Brand name Afinitor should be capitalized when used.

In Context

• "The patient was started on everolimus 10 mg daily for progressive pancreatic NET." — medication order
• "Everolimus therapy resulted in stable disease on follow-up imaging after six months." — treatment response