MEN1
Also written as: MEN1 — Multiple Endocrine Neoplasia Type 1
A hereditary syndrome causing multiple endocrine neoplasia affecting parathyroid, pancreas, and pituitary glands.
Full Definition
Multiple Endocrine Neoplasia Type 1 (MEN1) is an autosomal dominant genetic syndrome caused by mutations in the MEN1 gene encoding the protein menin. The syndrome is characterized by tumors in multiple endocrine glands, primarily the parathyroid glands, pancreatic islets, and anterior pituitary. Pancreatic neuroendocrine tumors in MEN1 patients include gastrinomas, insulinomas, and non-functional tumors. Patients require lifelong surveillance and management of multiple endocrine manifestations.
Usage
Usage note: The number should not be subscripted in standard medical text.
In Context
- "Genetic testing confirmed MEN1 syndrome in this patient with pancreatic NET and hyperparathyroidism." — genetics report
- "Family screening for MEN1 is recommended given the patient's multiple endocrine tumors." — clinical recommendation