MIBG scintigraphy
Pronunciation: MY-big sin-TIG-rah-fee
Nuclear medicine imaging using meta-iodobenzylguanidine to detect and localize catecholamine-secreting tumors.
Full Definition
MIBG (meta-iodobenzylguanidine) scintigraphy is a specialized nuclear medicine study that utilizes the structural similarity of MIBG to norepinephrine for tumor localization. This radiotracer is actively taken up by chromaffin cells and sympathetic nerve terminals, making it highly specific for pheochromocytomas and paragangliomas. The study involves injection of I-123 or I-131 labeled MIBG followed by whole-body imaging after 24-48 hours. While highly specific, MIBG scintigraphy has lower sensitivity than other imaging modalities, particularly for certain paraganglioma subtypes.
Usage
Usage note: Note that certain medications can interfere with MIBG uptake and should be discontinued before imaging.
In Context
- "MIBG scintigraphy demonstrated intense uptake in the right adrenal mass consistent with pheochromocytoma." — Nuclear medicine report
- "The negative MIBG scintigraphy result prompted consideration of alternative imaging modalities for tumor localization." — Diagnostic workup summary