Stimulated Thyroglobulin
Thyroglobulin levels measured after TSH stimulation to enhance sensitivity for detecting thyroid cancer recurrence.
Full Definition
Stimulated thyroglobulin refers to thyroglobulin measurements obtained when TSH levels are elevated, either through thyroid hormone withdrawal or recombinant human TSH (rhTSH) administration. TSH stimulation enhances thyroglobulin production from any residual thyroid tissue or thyroid cancer cells, improving the sensitivity of thyroglobulin as a tumor marker. This testing is typically performed 6-12 months after initial treatment and periodically thereafter for surveillance. The technique helps detect small amounts of residual disease that might not be apparent with suppressed thyroglobulin measurements obtained while patients are on thyroid hormone therapy.
Usage
Usage note: Often abbreviated as 'stim Tg'; distinguish from suppressed measurements.
In Context
- "Stimulated thyroglobulin remained undetectable following rhTSH administration." — Nuclear medicine report
- "The rising stimulated thyroglobulin level prompted whole-body scan imaging." — Endocrinology follow-up note