targeted molecular therapy
Also written as: TMT
Treatment approach using drugs that specifically target molecular pathways altered in neuroendocrine tumors.
Full Definition
Targeted molecular therapy encompasses treatments that specifically inhibit molecular pathways dysregulated in neuroendocrine tumors, such as the mTOR pathway, angiogenesis, or growth factor receptors. These agents work differently from traditional chemotherapy by targeting specific proteins or pathways essential for tumor growth and survival. Common examples in NET treatment include everolimus (mTOR inhibitor) and sunitinib (tyrosine kinase inhibitor). The selection of targeted therapies may be guided by tumor molecular characteristics, histologic subtype, and prior treatment history. These treatments often provide disease stabilization rather than dramatic shrinkage and may be associated with different toxicity profiles compared to conventional chemotherapy.
Usage
Usage note: Often provides disease stabilization rather than tumor shrinkage in NETs.
In Context
- "Targeted molecular therapy with everolimus showed progression-free survival benefit." — clinical trial report
- "Molecular profiling guided selection of targeted molecular therapy." — treatment rationale