thyroglobulin suppression
The reduction of thyroglobulin levels to undetectable ranges following thyroidectomy and radioactive iodine therapy in thyroid cancer patients.
Full Definition
Thyroglobulin suppression is a critical endpoint in differentiated thyroid cancer management, achieved through complete thyroidectomy and radioactive iodine remnant ablation. Successful suppression indicates elimination of all thyroid tissue, both normal and malignant. Thyroglobulin levels are measured while patients are on thyroid hormone suppression therapy, and undetectable levels suggest absence of residual or recurrent disease. This biomarker guides long-term surveillance strategies and risk stratification.
Usage
Usage note: Specify whether measured on or off thyroid hormone therapy, as interpretation differs significantly.
In Context
- "Successful thyroglobulin suppression to <0.2 ng/mL was achieved six months post-radioactive iodine therapy." — Endocrinology follow-up note
- "The absence of thyroglobulin suppression despite adequate treatment raised concern for persistent disease." — Multidisciplinary tumor board discussion