Chlorhexidine
Pronunciation: klor-HEK-si-deen
An antimicrobial agent used as an intracanal irrigant or medicament in endodontics, typically at a concentration of 0.2–2%.
Full Definition
Chlorhexidine (CHX) is a broad-spectrum bisbiguanide antiseptic used in endodontics as a supplementary irrigant, final rinse, or intracanal medicament, particularly in cases of persistent infection. Unlike sodium hypochlorite, it does not dissolve organic tissue but has substantivity—the ability to remain active on dentinal surfaces for an extended period. A critical editorial concern is the interaction between chlorhexidine and sodium hypochlorite: when mixed, they form a para-chloroaniline (PCA) precipitate that is potentially toxic and occludes dentinal tubules. Editors reviewing irrigation protocol descriptions must flag any text that omits the mandatory saline or EDTA rinse separating these two agents.
Usage
Usage note: Spell out in full on first use with 'CHX' in parentheses. Flag any protocol text that sequences chlorhexidine immediately after NaOCl without an intermediate rinse step.
In Context
- "A 2% chlorhexidine solution was used as the final irrigant before obturation to maximise substantivity." — Clinical protocol description
- "Editors should confirm that the irrigation sequence does not place chlorhexidine directly after NaOCl, as this produces a toxic precipitate." — Manuscript editing note