Kindling
A phenomenon where repeated subthreshold electrical stimulation eventually produces seizures.
Full Definition
Kindling is an experimental model of epileptogenesis in which repeated application of initially subthreshold electrical stimuli to brain tissue progressively increases neuronal excitability, ultimately resulting in spontaneous seizures. This process demonstrates how repeated, initially harmless stimulation can lead to permanent changes in brain excitability and seizure susceptibility. The kindling model has been instrumental in understanding the mechanisms underlying epilepsy development and has clinical relevance for understanding how repeated seizures may worsen epilepsy over time.
Usage
Usage note: Specifically refers to the epilepsy research model, not general neural plasticity phenomena.
In Context
- "The kindling model demonstrated progressive lowering of seizure threshold with repeated stimulation." — Preclinical research paper
- "Clinical observations support the kindling hypothesis that seizures beget seizures." — Epilepsy review article