Lateralization
The process of determining whether seizure activity originates from the left or right hemisphere of the brain.
Full Definition
Lateralization is a crucial step in presurgical evaluation that involves determining the hemispheric side of seizure onset through various diagnostic modalities. This process combines clinical semiology, EEG findings, neuroimaging, and neuropsychological testing to establish whether epileptic activity predominantly arises from left or right brain structures. Accurate lateralization is essential for surgical planning and helps predict potential cognitive risks associated with epilepsy surgery. Poor lateralization may indicate bilateral seizure onset or require additional invasive monitoring techniques.
Usage
Usage note: Often confused with 'localization' - lateralization refers specifically to left vs right hemisphere, while localization refers to specific brain regions within a hemisphere.
In Context
- "The patient's seizure semiology provided clear lateralization to the right hemisphere, with forced head turning to the left." — Epilepsy monitoring report
- "Despite multiple investigations, lateralization remained inconclusive, prompting consideration of bilateral implantation." — Surgical planning documentation