Professional
Technical
In the Industry Vocabulary Test
Refractory epilepsy
Epilepsy that fails to respond to adequate trials of anti-seizure medications.
Full Definition
Refractory epilepsy, also termed drug-resistant epilepsy, is defined as failure to achieve sustained seizure freedom despite trials of two tolerated and appropriately chosen anti-seizure medications. This classification triggers consideration for alternative treatments including epilepsy surgery, neurostimulation devices, or specialized diets. Editors must understand that refractory status significantly impacts treatment algorithms and requires documentation of specific medication trials with doses and durations.
Usage
Usage note: Requires documentation of specific failed medication trials. Use current terminology over 'intractable.'
In Context
- "The patient met criteria for refractory epilepsy after failing three appropriate ASM trials." — Epilepsy surgery referral
- "Refractory epilepsy prompted evaluation for responsive neurostimulation therapy." — Neurosurgery consultation
Also known as
drug-resistant epilepsy
intractable epilepsy
Contrasted with
controlled epilepsy
Don't confuse with
poorly controlled epilepsy