cystic adenomatoid malformation
Congenital lung lesion characterized by abnormal proliferation of bronchial structures forming cystic masses.
Full Definition
A developmental anomaly of the lung characterized by abnormal proliferation and cystic dilatation of terminal bronchioles, creating a mass-like lesion that replaces normal lung parenchyma. Also known as congenital pulmonary airway malformation (CPAM), these lesions are classified into five types based on cyst size and histological features. Type 1 lesions contain large cysts, while Type 2 have smaller uniform cysts. The condition may cause mediastinal shift, polyhydramnios, and fetal hydrops in severe cases. Many lesions decrease in size during pregnancy or resolve postnatally, but large lesions may require prenatal intervention or postnatal surgical resection.
Usage
Usage note: Abbreviated as CCAM or CPAM; newer terminology favors CPAM.
In Context
- "A large cystic adenomatoid malformation was detected in the right upper lobe causing mediastinal shift." — Fetal ultrasound report
- "The cystic adenomatoid malformation showed regression during the third trimester, avoiding the need for intervention." — Follow-up examination