MSAFP
Also written as: MSAFP — maternal serum alpha-fetoprotein
Maternal serum alpha-fetoprotein test used to screen for neural tube defects and chromosomal abnormalities during pregnancy.
Full Definition
Maternal serum alpha-fetoprotein (MSAFP) is a blood test performed during the second trimester of pregnancy, typically between 15-20 weeks gestation, to screen for certain birth defects. Alpha-fetoprotein is a protein produced by the fetal liver, and abnormal levels in maternal blood can indicate various conditions. Elevated levels may suggest neural tube defects, abdominal wall defects, or multiple gestations, while decreased levels may indicate increased risk of chromosomal abnormalities such as Down syndrome. This test is often part of a broader screening panel including other serum markers.
Usage
Usage note: Always specify 'maternal serum' to distinguish from amniotic fluid AFP.
In Context
- "MSAFP levels were reported as 2.5 multiples of the median, prompting referral for targeted ultrasound." — Laboratory screening report