Spina Bifida
Pronunciation: SPY-nah BIF-ih-dah
A neural tube defect characterized by incomplete closure of the vertebral column and spinal cord.
Full Definition
Spina bifida is a congenital neural tube defect resulting from failure of the neural tube to close completely during early embryonic development, typically occurring between days 17-30 of gestation. The condition involves incomplete formation of the vertebral arches, allowing the spinal cord and/or meninges to protrude through the defect. Three main types exist: spina bifida occulta (mildest form with intact skin), meningocele (meninges protrude), and myelomeningocele (most severe, with spinal cord involvement). Prenatal diagnosis can be made through elevated maternal serum alpha-fetoprotein, detailed ultrasound examination, or fetal MRI.
Usage
Usage note: Always use as two words; maintain the Latin spelling without anglicization.
In Context
- "The anomaly scan revealed spina bifida at the L3-L4 level with an associated Chiari II malformation." — Ultrasound diagnostic report
- "Fetal surgery was considered for the open spina bifida defect identified at 22 weeks." — Multidisciplinary consultation