HIPEC
Pronunciation: HY-pek
Also written as: HIPEC — hyperthermic intraperitoneal chemotherapy
A specialized surgical procedure combining tumor removal with heated chemotherapy delivered directly into the abdominal cavity.
Full Definition
Hyperthermic intraperitoneal chemotherapy (HIPEC) involves cytoreductive surgery followed by circulation of heated chemotherapy solution (typically 42-43°C) throughout the peritoneal cavity for 60-120 minutes. This approach targets microscopic residual disease following maximal tumor debulking in patients with peritoneal carcinomatosis. The hyperthermic component enhances drug penetration and cytotoxicity while the direct intraperitoneal delivery achieves high local concentrations with reduced systemic toxicity. HIPEC requires specialized centers with expertise in complex peritoneal surgery and critical care management due to significant procedure-related morbidity.
Usage
Usage note: Always capitalize entirely; specify chemotherapy agent and temperature when detailed protocol described.
In Context
- "The patient underwent cytoreductive surgery with HIPEC using mitomycin C." — Operative report
- "HIPEC demonstrated survival benefit in selected patients with limited peritoneal disease." — Clinical outcomes study