paradoxical reaction
Unexpected opposite response to medication, such as increased agitation from sedatives, particularly common in elderly patients.
Full Definition
A paradoxical reaction refers to an unexpected therapeutic response that is opposite to the intended effect of a medication. In geriatric psychiatry, this phenomenon is particularly concerning as elderly patients may experience increased agitation, confusion, or disinhibition when given sedating medications like benzodiazepines or antihistamines. These reactions can occur due to age-related changes in drug metabolism, polypharmacy interactions, or underlying cognitive impairment. Recognition of paradoxical reactions is crucial for medication safety and may require immediate discontinuation of the causative agent and alternative treatment approaches.
Usage
Usage note: More common in elderly patients; consider with any unexpected worsening after medication initiation.
In Context
- "The patient experienced a paradoxical reaction to lorazepam, becoming more agitated rather than sedated." — Incident report
- "Staff education emphasized recognizing paradoxical reactions to avoid inappropriate dose escalation." — Medication safety training