chemotherapy-induced peripheral neuropathy

Full Definition

Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting toxicity of several chemotherapy agents used in gynecologic oncology, particularly platinum compounds, taxanes, and vinca alkaloids. It typically presents as distal sensory symptoms including numbness, tingling, and pain in a stocking-glove distribution. Motor involvement may occur with severe cases. CIPN can significantly impact quality of life and may necessitate dose reductions or treatment discontinuation. Symptoms may be reversible but can persist long after treatment completion.

Usage

Usage note: Hyphenate the full term; CIPN is acceptable abbreviation after first use.

In Context

• "The patient developed grade 2 chemotherapy-induced peripheral neuropathy requiring dose modification." — treatment note
• "CIPN symptoms improved gradually over several months after treatment completion." — follow-up note