endometrial stromal sarcoma
Also written as: ESS — Endometrial Stromal Sarcoma
Rare malignant tumor arising from endometrial stromal cells, typically presenting with abnormal uterine bleeding.
Full Definition
Endometrial stromal sarcoma (ESS) is a rare malignant tumor that develops from the stromal cells of the endometrium, representing less than 1% of all uterine malignancies. These tumors are classified into low-grade and high-grade categories based on mitotic activity and cellular atypia. Low-grade ESS typically has an indolent course with tendency for late recurrence and metastasis to unusual sites like the lungs and pelvis. High-grade ESS behaves more aggressively with earlier metastasis and poorer prognosis. The tumors often present with abnormal uterine bleeding, pelvic pain, or an enlarged uterus. Treatment typically involves total hysterectomy with bilateral salpingo-oophorectomy, and hormonal therapy may play a role due to the hormone sensitivity of many ESS tumors.
Usage
Usage note: Always specify the grade (low-grade or high-grade) when documenting endometrial stromal sarcoma diagnoses.
In Context
- "The low-grade endometrial stromal sarcoma showed characteristic worm-like vascular invasion on histologic examination." — Pathology report
- "Given the hormone-sensitive nature of endometrial stromal sarcoma, aromatase inhibitor therapy was initiated postoperatively." — Treatment plan