hyperthermic intraperitoneal chemotherapy
Pronunciation: HI-pek
Also written as: HIPEC — Hyperthermic Intraperitoneal Chemotherapy
Heated chemotherapy delivered directly into the peritoneal cavity during surgery.
Full Definition
Hyperthermic intraperitoneal chemotherapy (HIPEC) is a specialized treatment modality that combines cytoreductive surgery with the direct administration of heated chemotherapy into the peritoneal cavity. The chemotherapy solution is heated to 41-43°C and circulated throughout the abdomen for 60-90 minutes during the surgical procedure. This approach aims to eliminate microscopic residual disease after optimal debulking in select patients with peritoneal surface malignancies, including some gynecologic cancers.
Usage
Usage note: Always specify the chemotherapy agent and temperature parameters when documenting.
In Context
- "The patient underwent optimal debulking followed by HIPEC with cisplatin." — operative report
- "Hyperthermic intraperitoneal chemotherapy is being investigated as consolidation therapy in ovarian cancer." — clinical trial protocol