intraperitoneal chemotherapy
Direct delivery of chemotherapy into the peritoneal cavity to maximize local drug concentration.
Full Definition
Intraperitoneal (IP) chemotherapy involves the direct instillation of chemotherapy agents into the peritoneal cavity through a surgically placed catheter or port. This route of administration achieves higher local drug concentrations while limiting systemic exposure and toxicity. IP chemotherapy has shown survival benefits in optimally debulked advanced ovarian cancer when combined with intravenous chemotherapy. Common agents used include cisplatin and paclitaxel. Treatment requires specialized expertise and careful patient selection due to increased complexity and potential complications.
Usage
Usage note: Distinguish from HIPEC which involves heated chemotherapy during surgery.
In Context
- "The patient was considered for intraperitoneal chemotherapy following optimal cytoreduction." — treatment planning note
- "IP chemotherapy administration requires specialized nursing protocols and monitoring." — nursing procedure manual