krukenberg tumor
Pronunciation: KROO-ken-burg
Metastatic ovarian tumor, typically from gastrointestinal primary malignancies, characterized by signet ring cells.
Full Definition
A Krukenberg tumor is a metastatic ovarian malignancy that originates from a primary cancer elsewhere in the body, most commonly from the gastrointestinal tract, particularly the stomach. These tumors are characterized histologically by the presence of signet ring cells and mucin production. Krukenberg tumors typically present as bilateral ovarian masses and may be discovered before, simultaneously with, or after the primary tumor diagnosis. The prognosis is generally poor due to the advanced nature of disease when ovarian metastases are present. Treatment focuses on managing the primary malignancy, and surgical removal of ovarian metastases is typically performed for symptom relief rather than cure. The term is also used more broadly to describe any metastatic tumor to the ovary with signet ring cell morphology.
Usage
Usage note: Always investigate for a gastrointestinal primary when diagnosing Krukenberg tumors.
In Context
- "The bilateral ovarian masses with signet ring cells on pathology were consistent with Krukenberg tumors from her known gastric primary." — Pathology consultation
- "Extensive imaging workup was performed to identify the primary source of the suspected Krukenberg tumor." — Diagnostic evaluation