platinum-resistant
Cancer that progresses during or within six months of completing platinum-based chemotherapy treatment.
Full Definition
Platinum-resistant ovarian cancer is defined as disease that progresses during platinum-based treatment or recurs within six months of completing a platinum-containing regimen. This classification is crucial for treatment planning as platinum-resistant cancers show poor response rates to additional platinum therapy and require alternative treatment approaches. The distinction is made based on the platinum-free interval, with resistance indicating a more aggressive disease biology and generally poorer prognosis. Treatment options for platinum-resistant disease include non-platinum chemotherapy agents, targeted therapies, and clinical trials.
Usage
Usage note: Hyphenate as platinum-resistant; six-month cutoff distinguishes from platinum-sensitive (>6 months).
In Context
- "The patient's disease recurred four months after carboplatin completion, classifying it as platinum-resistant." — Oncology assessment
- "Given the platinum-resistant status, treatment was changed to pegylated liposomal doxorubicin." — Treatment modification note