intraperitoneal chemotherapy
Administration of chemotherapeutic agents directly into the peritoneal cavity for treatment of ovarian cancer.
Full Definition
Intraperitoneal (IP) chemotherapy involves the direct administration of chemotherapeutic drugs into the peritoneal cavity through a surgically placed catheter or port system. This approach is primarily used in the treatment of optimally debulked advanced ovarian cancer, where it provides higher local drug concentrations while reducing systemic toxicity. IP therapy typically involves alternating cycles of intravenous and intraperitoneal drug administration. Common agents used include cisplatin and paclitaxel. While IP chemotherapy has shown survival benefits in clinical trials, it is associated with increased toxicity and catheter-related complications compared to standard intravenous therapy.
Usage
Usage note: Often abbreviated as 'IP chemo' in informal documentation.
In Context
- "The patient completed six cycles of intraperitoneal chemotherapy with cisplatin and paclitaxel." — Oncology progress note
- "Catheter-related complications are more frequent with intraperitoneal chemotherapy than IV administration." — Clinical trial report