ASCUS
Pronunciation: AS-kus
Also written as: ASCUS — atypical squamous cells of undetermined significance
Atypical squamous cells of undetermined significance, a Pap smear result indicating mildly abnormal cervical cells.
Full Definition
Atypical squamous cells of undetermined significance (ASCUS) is the most common abnormal Pap smear result, representing cellular changes that are more pronounced than normal reactive changes but lack sufficient features to definitively classify as dysplasia. ASCUS results account for approximately 3-5% of all Pap smears and may indicate infection, inflammation, or early precancerous changes. The standard management approach includes either immediate HPV testing (reflex HPV testing) or repeat cytology in 6-12 months. If high-risk HPV is detected or if ASCUS persists, colposcopy is typically recommended to further evaluate the cervix for significant lesions.
Usage
Usage note: Part of the Bethesda System for reporting cervical cytology; distinguish from ASC-H (cannot exclude high-grade lesion).
In Context
- "The Pap smear showed ASCUS with positive high-risk HPV, prompting referral for colposcopy." — Cytology report
- "Management of ASCUS in patients under 25 typically involves repeat cytology rather than immediate colposcopy." — Clinical guideline