endometrial hyperplasia
Abnormal thickening of the uterine lining that may progress to malignancy if left untreated.
Full Definition
Endometrial hyperplasia refers to the abnormal proliferation and thickening of the endometrium (uterine lining) beyond normal physiological limits. This condition occurs when there is prolonged estrogen stimulation without adequate progesterone opposition, leading to glandular crowding and architectural changes. The condition is classified as either simple or complex, and with or without atypia, with atypical complex hyperplasia carrying the highest risk of progression to endometrial adenocarcinoma. Diagnosis is typically made through endometrial sampling or hysteroscopy with targeted biopsy. Treatment options range from hormonal management with progestins to hysterectomy in severe cases or when fertility is not desired.
Usage
Usage note: Always specify whether hyperplasia is simple or complex, and with or without atypia, as this affects treatment decisions.
In Context
- "The pathology report confirmed complex endometrial hyperplasia without atypia." — Pathology report
- "Given the patient's age and completed childbearing, hysterectomy was recommended for atypical endometrial hyperplasia." — Consultation note