HSIL
Pronunciation: aitch-sil
Also written as: HSIL — High-Grade Squamous Intraepithelial Lesion
High-grade squamous intraepithelial lesion, representing moderate to severe cervical dysplasia that requires prompt evaluation and treatment.
Full Definition
High-grade squamous intraepithelial lesion (HSIL) is a cytological diagnosis indicating moderate to severe dysplasia of cervical squamous cells, corresponding to CIN 2 or CIN 3 in histological terminology. HSIL represents precancerous changes with significant potential for progression to invasive cervical cancer if left untreated. This diagnosis typically results from persistent high-risk HPV infection and requires immediate colposcopic evaluation with directed biopsies. Management usually involves excisional procedures such as LEEP or cone biopsy to remove the abnormal tissue and provide histological diagnosis.
Usage
Usage note: Part of Bethesda System terminology; distinguish from histological grading (CIN 2/3).
In Context
- "The Pap test result showed HSIL, prompting urgent referral for colposcopy." — cytology report
- "HSIL on cervical cytology requires immediate evaluation due to cancer risk." — clinical guideline