esthesioneuroblastoma
Pronunciation: es-thee-zee-oh-nyur-oh-blas-TOH-mah
Rare malignant neuroectodermal tumor arising from the olfactory epithelium in the nasal cavity.
Full Definition
Esthesioneuroblastoma, also known as olfactory neuroblastoma, is a rare malignant tumor that arises from the specialized neuroectodermal olfactory epithelium in the superior nasal cavity and cribriform plate region. The tumor typically presents with unilateral nasal obstruction, anosmia, and epistaxis, and may extend intracranially through the cribriform plate. Diagnosis requires immunohistochemical staining for neural markers, and the Kadish staging system is commonly used for prognostication. Treatment typically involves a multidisciplinary approach with surgical resection and adjuvant radiation therapy.
Usage
Usage note: Also known as olfactory neuroblastoma; pronunciation guidance often needed.
In Context
- "MRI demonstrated a heterogeneous mass extending through the cribriform plate, consistent with esthesioneuroblastoma." — Radiology report
- "The Kadish C esthesioneuroblastoma required craniofacial resection with neurosurgical collaboration." — Operative plan