keratosis
Pronunciation: ker-ah-TOH-sis
Thickened, hyperkeratinized epithelial lesion that may represent premalignant change in head and neck mucosa.
Full Definition
Keratosis refers to focal thickening and hyperkeratinization of epithelial surfaces, commonly observed in the oral cavity and other head and neck mucosal sites. In head and neck oncology, keratotic lesions are significant because they may represent premalignant changes such as leukoplakia or erythroplakia. These lesions require careful evaluation including biopsy to determine the degree of dysplasia present. The presence of keratosis may indicate chronic irritation, tobacco use, or other carcinogenic exposures that increase cancer risk.
Usage
Usage note: Always specify anatomical location and whether biopsy was performed for keratotic lesions.
In Context
- "Multiple areas of keratosis were noted on the lateral tongue borders during examination." — Clinical examination note
- "Biopsy of the keratotic lesion revealed severe dysplasia requiring close surveillance." — Pathology report