allogenic stem cell transplantation
A therapeutic procedure involving the transfer of hematopoietic stem cells from a genetically different donor to a recipient.
Full Definition
Allogenic stem cell transplantation is a curative treatment modality for various hematologic malignancies, involving the infusion of hematopoietic stem cells harvested from a genetically distinct donor into a recipient patient. The procedure requires intensive conditioning regimens to eliminate malignant cells and suppress the recipient's immune system to prevent graft rejection. Success depends on human leukocyte antigen (HLA) compatibility between donor and recipient. Complications include graft-versus-host disease, infections, and organ toxicity.
Usage
Usage note: Note the spelling 'allogenic' not 'allogeneic' - both are acceptable but 'allogeneic' is more common in medical literature.
In Context
- "The patient underwent allogenic stem cell transplantation from a matched sibling donor." — Treatment summary
- "Conditioning regimens for allogenic stem cell transplantation vary based on patient age and disease status." — Protocol guidelines