bulky disease
Lymphoma masses exceeding specific size criteria, typically 10 cm in diameter. Affects staging and treatment planning.
Full Definition
Bulky disease refers to lymphomatous masses that exceed defined size thresholds, commonly 10 cm in the greatest dimension for nodal masses or one-third of the thoracic diameter for mediastinal masses. This designation is clinically significant as it often indicates more aggressive disease requiring intensified treatment approaches. Bulky disease can affect staging classification and is considered an adverse prognostic factor in many lymphoma subtypes. Treatment protocols may specify different chemotherapy regimens or radiation therapy fields for patients with bulky disease.
Usage
Usage note: Use lowercase unless beginning a sentence. Specify measurement criteria when mentioned in formal protocols.
In Context
- "The patient presented with bulky mediastinal disease measuring 12 cm." — Clinical note
- "Bulky disease at diagnosis is associated with inferior progression-free survival." — Research manuscript