cytarabine
Pronunciation: sy-TAIR-ah-been
A chemotherapy drug commonly used in the treatment of acute leukemias and some lymphomas, also known as ara-C.
Full Definition
Cytarabine (ara-C) is a synthetic nucleoside analog chemotherapy agent that is a cornerstone of treatment for acute myeloid leukemia and some forms of acute lymphoblastic leukemia. The drug works by interfering with DNA synthesis in rapidly dividing cells, preferentially affecting cancer cells. Cytarabine is administered intravenously in various dosing regimens, from standard-dose to high-dose protocols, depending on the specific indication and treatment phase. Common side effects include myelosuppression, gastrointestinal toxicity, and at high doses, cerebellar toxicity.
Usage
Usage note: Both cytarabine and ara-C are acceptable; ensure proper spelling to avoid confusion with similar drug names.
In Context
- "High-dose cytarabine was administered for consolidation therapy in AML." — Chemotherapy protocol
- "The patient experienced cerebellar toxicity following ara-C treatment." — Adverse event report