cytokine release syndrome
Also written as: CRS — Cytokine Release Syndrome
Acute systemic inflammatory response caused by massive cytokine release, often following immunotherapy.
Full Definition
Cytokine release syndrome (CRS) is a potentially life-threatening systemic inflammatory condition characterized by widespread activation of immune cells and massive release of pro-inflammatory cytokines. It commonly occurs following CAR-T cell therapy, bispecific antibody treatments, or other immunotherapies. Symptoms range from fever and fatigue to severe hypotension, respiratory failure, and multi-organ dysfunction. Grading systems exist to standardize severity assessment, with treatments including tocilizumab and corticosteroids. The term should not be confused with tumor lysis syndrome or graft-versus-host disease.
Usage
Usage note: Capitalize when referring to the specific medical condition; lowercase for general cytokine release
In Context
- "Grade 2 cytokine release syndrome was managed with tocilizumab and supportive care." — Clinical case report
- "Cytokine release syndrome remains the most common serious adverse event following CAR-T cell infusion." — Safety analysis