Professional
Technical
IVT
dysplastic changes
Pronunciation: dis-PLAS-tik changes
Abnormal cellular morphology indicating disordered development or maturation in hematopoietic cells.
Full Definition
Dysplastic changes refer to morphologic abnormalities in blood cells that indicate faulty maturation and development within the bone marrow. These changes are hallmarks of myelodysplastic syndromes but can also occur in acute leukemias and following chemotherapy. Common dysplastic features include nuclear-cytoplasmic asynchrony, abnormal granulation, and irregular nuclear contours. Recognition of these changes is crucial for diagnosis and distinguishing between reactive conditions and clonal hematopoietic disorders.
In Context
- "Bone marrow examination revealed significant dysplastic changes in all three cell lines." — Pathology report
- "The presence of dysplastic changes supported a diagnosis of myelodysplastic syndrome." — Diagnostic summary
Also known as
dysplasia
dysmorphic features
Contrasted with
normal morphology
typical maturation
Don't confuse with
atypical cells
reactive changes