Hodgkin lymphoma
A type of lymphoma characterized by the presence of Reed-Sternberg cells and typically spreads in an orderly fashion from one lymph node group to adjacent groups.
Full Definition
Hodgkin lymphoma is a distinct form of lymphoid malignancy characterized histologically by the presence of Reed-Sternberg cells or their variants within an inflammatory background. Unlike non-Hodgkin lymphomas, Hodgkin lymphoma typically spreads in a contiguous, predictable pattern from one lymph node group to adjacent groups. The disease is classified into classical Hodgkin lymphoma (which includes several subtypes) and nodular lymphocyte-predominant Hodgkin lymphoma. Treatment typically involves chemotherapy with or without radiation therapy, and the prognosis is generally favorable, especially in early-stage disease.
Usage
Usage note: Modern terminology favors 'Hodgkin lymphoma' over 'Hodgkin disease'; always distinguish from non-Hodgkin lymphoma.
In Context
- "The lymph node biopsy confirmed Hodgkin lymphoma with Reed-Sternberg cells present." — pathology report
- "ABVD chemotherapy remains a standard treatment regimen for advanced Hodgkin lymphoma." — treatment guideline