induction chemotherapy
Initial intensive treatment phase designed to rapidly reduce tumor burden and achieve remission.
Full Definition
Induction chemotherapy represents the first phase of treatment for acute leukemias and aggressive lymphomas, employing high-dose, multi-agent regimens to rapidly reduce disease burden and achieve complete remission. This intensive approach targets rapidly dividing cancer cells but also affects normal tissues, particularly bone marrow, leading to significant treatment-related toxicities including severe cytopenias and increased infection risk. The success of induction therapy is typically measured by achieving complete remission, defined by specific morphologic, cytogenetic, and molecular criteria. Induction is typically followed by consolidation or maintenance phases.
Usage
Usage note: Distinguish from 'induction of chemotherapy' which implies causation rather than treatment phase
In Context
- "The patient achieved complete remission following standard induction chemotherapy with daunorubicin and cytarabine." — Clinical progress note
- "Induction chemotherapy toxicities required supportive care including growth factor support and antimicrobial prophylaxis." — Treatment protocol