Professional
Technical
IVT
kappa/lambda ratio
Pronunciation: KAP-ah LAM-dah ratio
The ratio of kappa to lambda light chains, used to detect clonal plasma cell populations.
Full Definition
The kappa/lambda ratio compares the levels of kappa and lambda immunoglobulin light chains in serum or urine to assess for clonal plasma cell disorders. Normal serum ratios range from approximately 0.26 to 1.65, while abnormal ratios suggest monoclonal proliferation. This test is crucial for diagnosing and monitoring plasma cell dyscrasias, including multiple myeloma and light chain amyloidosis. An involved/uninvolved light chain ratio ≥100 is one of the biomarkers for active myeloma.
Usage
Usage note: May be written with Greek letters (κ/λ) or spelled out; maintain consistency within documents.
In Context
- "The serum kappa/lambda ratio was markedly elevated at 45:1, indicating clonal excess." — Laboratory interpretation
- "Serial monitoring of the kappa/lambda ratio showed improvement following treatment." — Follow-up assessment
Also known as
light chain ratio
κ/λ ratio
Don't confuse with
heavy chain ratio
immunoglobulin ratio